Pacific Hematology Oncology Associates
  • Staff Physicians >
  • Kathleen Grant, M.D.
  • Bertrand Y. Tuan, M.D.
  • Ari D. Baron, M.D.
  • Caroline Marie Behler, M.D.
PHOA Doctors
  • Current Title
  • Education
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  • Professional Experience
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  • Awards & Special Activities
  • Research & Publications

Kathleen Grant, M.D.
Medical Oncologist-Hematologist
Chief, Division of Medical Oncology-Hematology
Private Practice of Medical Oncology-Hematology
California Pacific Medical Center
San Francisco, CA

Education

Undergraduate
1966
Summa cum laude, English Literature and Zoology
Univeristy of Minnesota, Minneapolis, MN

Graduate
1970
Doctor of Medicine
University of Minnesota School of Medicine
Minneapolis, MN

Postgraduate Training
1970 - 71
Intern in Medicine
Presbyterian Hospital
San Francisco, CA

1971-73
Resident in Pathology
Presbyterian Hospital, San Francisco, CA

1973-75
Resident in Internal Medicine Presbyterian Hospital, San Francisco, CA

1975 - 78
Fellow in Hematology-Oncology
University of California, San Francisco, CA

Board Certification
Board Certification in Internal Medicine, 1975
Board Certification in Hematology, 1978
Board Certification in Medical Oncology, 1979

Medical Licensure
1971 State of Minnesota
1972 State of California, (C34434)

Professional Experience
1978 - Present
Private practice of Medical Oncology and Hematology
San Francisco, CA

1978 - Present
Member of Attending Staff,
California Pacific Medical Center
San Francisco, CA

1978 - 94
Chief, Division of Oncology
Pacific Presbyterian Medical Center
San Francisco, CA

1982 - 92
Director, Adult Oncology Unit,
Pacific Presbyterian Medical Center
San Francisco, CA

1992 - Present
Member, Board of Directors, Pan Med Ltd.,
Pacific Professional Building
San Francisco, CA

1996 - Present
Member, Board of Directors, Expedition Inspiration Fund
for Breast Cancer Research

1997 - Present
Chief, Division of Hematology and Oncology
California Pacific Medical Center
San Francisco, CA

Associations

American Society of Clinical Oncology

American Society of Hematology

San Francisco Medical Association

California Medical Association

Breast Cancer Action

Medical Staff Activities
1982 - 1984
Member, Medical Staff Executive Committee
California Pacific Medical Center
San Francisco CA

1984 - 1992
Chairman, Cancer Committee
California Pacific Medical Center
San Francisco, CA

1992 - Present
Member, Cancer Committee
California Pacific Medical Center
San Francisco, CA

1992 - 2007
Chairman, Oncology Quality Improvement Subcommittee
California Pacific Medical Center
San Francisco, CA

2003 - Present
Chairman, Oncology Suppor tive Services Subcommittee
California Pacific Medical Center
San Francisco, CA

Awards and Special Activities
1979
Golden Shovel Award for Best Teacher
Pacific Presbyterian Medical Center
San Francisco, CA

1995
Team Physician Expedition Inspiration, Breast Cancer
Survivors’ Climb of 23,000 ft. Mt. Aconcagua, Argentina

1995
Honored by Assembly Resolution No. 623
California Legislature
Sacramento, CA

1996
Contributor, Time-Life Videos Educations Series,
Colorectal Cancer

1996
Outstanding Researcher Award
California Pacific Medical Center
San Francisco, CA

1999
Breast Center Fund-raiser, Expedition Inspiration
Mt. Kilimanjaro, Kenya

Community Outreach
Big Sisters African American Breast Cancer Project
Sister to Sister Breast Cancer Program

Research Activities
Phase I trial of Immunotoxin (MoAb-RTA) in Colorectal Cancer.

Phase I trial of Immunotoxin (Moab - TRA) in Melanoma.

Southwest Oncology Group, National Surgical Adjuvant Breast and Bowel Project, West Bay Sutter Research Consortium

Publications

1. Grant K, Rodvien R, and Mielke CH, Jr.: “Altered Factor VIII in Acute Respiratory Failure.” Abstract #54. American Society of Hematology 19th Annual Meeting, Boston, Mass., Dec. 4-7, 1976

2. Grant K, Rodvien R, and Mielke CH: “Altered Factor VIII Complexes in Patients with Respiratory Insufficiency.” Thrombosis and Haemostasis, 40:326, 1978

3. Petz L, Gitlin J, Grant KM, Rodvien R, and Brotman M: Cimetidine-Induced Hemolytic Anemia: The Fallacy of Clinical Associations. J. Clin. Gastroent. 5:405-409, 1983

4. Ziegler JL, Bragg K, Abrams D, Beckstead J, Cogan M, Volberding P, Baer D, Wilkinson L, Rosenbaum E, Grant K, et al. “High Grade Non-Hodgkin’s Lymphoma in Patients with AIDS.” Ann. NY Acad Sci 437:412-419, 1985.

5. Schoeppel S, Hoppe R, Abrams D, Baer D, Grant K, Horning S, Wilkinson L, Zeigler J: “Hodgkin’s Disease in Homosexual Men - The San Francisco Bay Experience.” Proceedings of American Society of Clinical Oncology #9, vol 5:3, 1986.

6. Bermudez MA, Grant KM, Rodvien R: Lymphoma in a Population With or At Risk for AIDS - Single Institution Experience. Blood (supp 1) 68(5):127 abstract #363, Nov., 1986.

7. Bermudez M, Grant K, Rodvien R: Non-Hodgkin’s Lymphoma in a Population With or At Risk for Acquired Immunodeficiency Syndrome: Indications for Intensive Chemotherapy. American Journal of Medicine 86:71-76, 1989.

8. Poplin E, Fleming T, MacDonald JS, Rodvien R, Grant K, Fisher R: Amonafide Treatment of Refractory Esophageal Cancer.A Southwest Oncology Group Study, IND 11:47-51, 1993.

9. Parthasarathy A, Glaubiger D, Grant KM, Baron AD: “Treatment of Anal Carcinoma in HIV Positive Males: A Single Institution Experience”. American Society of Oncology, 2006 Gastrointestinal Cancers Symposium; abstract #640.

  • Current Title
  • Training & Professional Positions
  • Education
  • Licenses & Certifications
  • Academic & Hospital Appointments
  • Memberships
  • Biography

Bertrand Y. Tuan, M.D.
Hematologist-Oncologist
Pacific Hematology-Oncology Associates
California Pacific Medical Center
San Francisco, CA

Training and Professional Positions
1994 - Present
Physician, Pacific Hematology-Oncology Associates
California Pacific Medical Center
San Francisco, CA.

1993-1994
Emergency Room Physician
St. Luke's Hospital, New Bedford, MA
Malden Hospital, Malden, MA
New England Memorial Hospital, Stoneham, MA

Locum Tenems Hematology-Oncologyfor the practices of
Barbara Bjornson, M.D. and Roberto Mattii, M.D.,
Malden, MA.

1992-1993
Associate Physician, Divisions of Experimental Medicine and
Hematology/Oncology, Brigham and Women's Hospital
Boston, MA.

Instructor in Medicine, Harvard Medical School
Boston, MA

1989-1991
Clinical and Research Fellow in Medicine
Hematology/Oncology, Massachusetts General Hospital
Boston, MA.

1988-1989
Emergency Room Physician, Malden Hospital
Malden, MA.

1985-1988
Internship and Residency in Internal Medicine
Boston City Hospital, Boston, MA.

Education
1985
Albert Einstein College of Medicine, Bronx, N.Y.v M.D.

1981
University of California, Berkeley, CA.
A.B. in Biophysics with Honors.

Board Certifications

Medical Oncology

Hematology

Internal Medicine

Licensure and Certification

Diplomate, American Board of Intemal Medicine:

• Medical Oncology, 1993

• Hematology, 1992, 2002

• Intemal Medicine, 1988

Diplomate, National Board of Medical Examiners

Califomia Medical License No. GO78339

Academic Appointments
1992-1993
Instructor in Medicine
Harvard Medical School

1989-1992
Research Fellow in Medicine
Harvard Medical School

Hospital Appointments
1994
Medical Staff Member
Califomia Pacific Medical Center
San Francisco, CA

1993-1994
Medical Staff Member
Malden Hospital, Malden, MA.
New England Memorial Hospital, Stoneham, MA.
Whidden Hospital, Everett, MA

1992-1993
Associate Physician
Brigham and Women's Hospital

1989-1991
Clinical and Research Fellow in Medicine
Massachusetts General Hospital

Memberships

American Society of Hematology

American Society of Clinical Oncology

Research Activities
1990-1993
Hematology/Oncology Research Fellow with Thomas Stossel, M.D. and David Kwiatkowski, M.D., Ph.D. Massachusetts General Hospital and Brigham and Women's Hospital,

Study of the effects of over expression of the act in-binding protein Gelsolin and deletion mutants of gelsolin on cellular motility and cellular transformation.

1984
Medical Student Research Associate with Karl Weisgraber, Oh. D., Gladstone Foundation Laboratories for Cardiovascular Research, University of California,
San Francisco.

Developed an assay using oligonucleotides to detect apolipoprotein E genetic polymorphisms

1981
Research Associate with Karl Weisgraber, Ph.D.
Glastone Foundation Laboratories

Analyzed Apolipoprotein B structure

1980-1981
Senior Honors Thesis Research with Alex Nichols, Ph. D.,
Department of Biophysics, University of California,

Studied the effects of dietary cholesterol on electrophoretic Patterns of baboon lipoproteins

  • Current Title
  • Education
  • Licences & Certifications
  • Principle Positions Held
  • Honors & Awards
  • Professional Affiliation
  • University & Community Service
  • Research, Publications & Lectures

Ari D. Baron, M.D.
Hematologist-Oncologist
Pacific Hematology-Oncology Associates
California Pacific Medical Center
San Francisco, CA,
September 1996 - Present

Associate Clinical Professor
Department of Medicine, University of California
San Francisco, CA
June 2004 - Present

Medical Director
Clinical Oncology Research Program
California Pacific Medical Center
San Francisco, CA, December 2007 - Present

Medical Director
GI Oncology Section
California Pacific Medical Center
San Francisco, CA, December 2007 - Present

Education
Wesleyan University
Middletown, CT
B.A. in English, 1984

Tufts University School of Medicine
Boston, MA, M.D., May 1990

University of California, San Francisco
Department of Medicine, San Francisco, CA
Medical Residency, June 1993.

University of California, San Francisco
Division of Hematology-Oncology, San Francisco, CA
Hematology-Oncology Fellowship
July 1994-September, 1996.

University of California, San Francisco
Department of Epidemiology and Biostatistics, San Francisco, CA
Outcomes Research and Clinical Epidemiology
August, 1996

Licenses and Certifications
California Medical license: G072619 since October 1991

Diplomate, American Board of Internal Medicine
September 1993

Diplomate, ABIM: Medical Oncology
November 1997

Principle Positions Held
Staff Physician
Veterans Administration Medical Center
San Francisco, CA
July 1993 - July 1994

Staff Physician
San Francisco General Hospital Emergency Services
San Francisco, CA
July 1993 - July 1996

Clinical Instructor
Department of Medicine, University of California,
San Francisco, CA
July 1993 - June 1994 & July 1995 – June 1997

Assistant Clinical Professor
Department of Medicine, University of California,
San Francisco, CA
June 1997 – June 2004

Clinical Associate
Department of Epidemiology & Biostatistics, UCSF
July 1995 – June 1996

Honors and Awards

Joseph Collins Foundation Grand,based on academic achievement and demonstrated interest in the arts and letters, 1988 - 1990

Alpha Omega Alpha,National Medical Honors Society,
October 1989

Julius Krevans Award for clinical excellence, Department of Medicine,
University of California, San Francisco, April 1991. Awarded to outstanding intern.

Excellence in Teaching Award, Department of Medicine,
University of California, San Francisco, 1995. Awarded to outstanding teacher among clinical fellows by medicine house staff.

Professional Affiliation
San Francisco Interns and Residents Association
1990 - 1993

Massachusetts Medical Society
1986 - Present

American College of Physicians
1993 - Present

San Francisco Medical Society
September 1996 - Present

American Society of Clinical Oncology
Active Member
July, 1996 - Present

University Service
Interdepartmental Task Force to establish disability insurance coverage for housestaff. University of California, San Francisco Medical Center, 1991.

Fellowship education committee, established to review and redesign training program. Division of Hematology-Oncology, University of California, San Francisco, Fall 1995.

Interviewer, Internal Medicine Residing Program, California Pacific Medical Center, University of California, San Francisco, 1998 - 2002.

Anticoagulation Quality Assurance: Developed guidelines and teaching tools to improve safety of anticoagulation. California Pacific Medical Center, San Francisco, 1997-1998.

Chairman, Science Committee, California Pacific Medical Center, San Francisco, CA. Develop and administer clinical research program in oncology for largest private hospital in northern California. 2001-present

Community Service
Co-founder, Student, Student Committee on Racial Awareness, Wesleyan University, Middletown, CT. Developed and led workshops on racism on campus. 1981 - 1984.

Co-founder, AIDS Education Group, Tufts University School of Medicine, Boston, MA. Developed and led workshops on AIDS education for resident advisors, Tufts undergraduate campus. Fall 1986.

Co-founder Member, Kids in Chemotherapy Support. Helped start group of Big Brothers and Sisters to support children with cancer. New England Medical Center, sBoston Floating Hospital for Children. 1987 - 1989.

Member, Board of Directors, Patient Assistance Foundation. California Pacific Medical Center, San Francisco, CA June, 2007.

Member, Board of Directors, Developing Indigenous Resources, a non-profit organization committed to health care in India. June, 2007.

Research Experience
Research Technician, Division of Cell Biopsy, Children’s Hospital, Boston, MA. Independently involved in the investigation of the structure and regulation of the acute phase response genes of the human immune system. 1984 - 1986.

Clinical Research Intern, Division of Adult Oncology, Hammersmith Hospital, London. Followed patients in Phase II clinical trial of radiolabeled monoclonal antibodies against ovarian cancer. Summer 1986.

Publications
“Sweet’s Syndrome During G-CSF Therapy.” Parks, J. Mehrotra, B., Barnett, B., Baron, A., Venook, A. Annals of Internal Medicine, 1992; 116:996-999

“Pseudomonas aeruginosa Bronchopulmonary Infection in Late HIV Disease.” Baron, A. and Hollander, H. Presented at the 8th International AIDS Conference, Amsterdam, July 1992. American Review of Respiratory Diseases, 1993; 148:992-6

“Ketoconazole Retains Activity in Advanced Prostate Cancer Patients Who Have Progressed Despite Flutamide Withdrawal.” Small, EJ., Baron, A.D., Fippin, L. Journal of Urology, 1997; 157:1204-07

“Simultaneous Anti-androgen Withdrawal and Treatment with Ketoconazole in Patients with Advanced Hormone Refractory Prostate Cancer.” Small, E.S., Baron, A.D., Bok R. ASCO Abstract # 1117, 1997. Cancer 1997; 80:1755-9

“Addition ofBevacizumab (rhuMab VEGF) to Bolus IFL in the First-Line Treatment of Patients With Metastatic Colorectal Cancer: Results of a Randomized Phase III Trial.” Hurwitz, Fehrenbacher, Novotny, Car twright, Hainsworth, Heim, Berlin, Baron, Griffing, Holmgren, Ferrara, Fyfe, Rogers, Ross, Kabbinnavar New England Journal of Medicine 2004;350:2335-42.

“A Phase 2a Trial of Weekly Patupilone ( EPO 906) in Patients With Hormone- Refractory Prostate Cancer (HRPC.)” Hussain, Dipaola, Baron, Higano, Tchekmedyian, Miller, Rothermel ProcASCO 2004, Abstract # 4563. Annals of Oncology 2009 20(3):492-497.

“Influence of Hepatic Dysfunction on Safety, Tolerability and Pharmacokinetics of PTK787/ZK 222584 in Patients with Unresectable Hepatocellular Carcinoma.” Koch, Baron, Roberts, Junker, Palacay-Ramona, Masson, Laurent, Kay, Wiedenmann, Cebon. ProcASCO 2005. Abstract # 4134.

“Traztuzumab and Vinorelbine or Taxane Chemotherapy for Her2+ Metastatic Breast Cancer : the TRAVIOTA Study.” H. Burstein, A. Keshaviah, A. Baron, R. Har t, R. Lambert-Falls, P. Marcom, R. Gelman, E. Winer ProcASCO 2006, Abstract # 650, and Cancer 2007; 110: 965-972.

“A Randomized Multicenter Study to Determine the Safety and Efficacy of the Immunoconjugate SGN-15 Plus Docetaxel for the Treatment of Non-Small Cell Lung Carcinoma.” H.Ross, L. Har t, P. Swanson, M. Rarick, R. Figlin, A. Jacobs, D. McCune, A. Rosenberg, A. Baron, L. Grove, M. Thorn, D. Miller, A. Sing, J. Drachman, C. Rudin Lung Cancer 2006; 54, 69-77

“Hepatocellular Carcinoma: Current and Evolving Therapies.” Gish, R and Baron, A., IDrugs 2008 11(3): 198-203

Lectures
Prostate Cancer : Current Controversies and Advances, Medical Grand Rounds, California Pacific Medical Center, 4-97, Marin General, 12-97, Davies Medical Center, 1-98, Hawaiian Urologic Association, 1-98, John Muir Medical Center 7-98, San Francisco General Hospital 7-98, St. Mary’s Medical Center 1-00, Phoenix Urological Association, 2002, Tuscon VAMC 2002.

Lung Cancer : Update on Current Treatment, Kaiser Permanente, 12-97, Marin General Hospital 12-98, Good Samaritan Hospital, San Jose,2003, Alvarado Hospital,, San Diego 11-2006.

Hypercoagulability and Its Treatment, Medical Grand Rounds, California Pacific Medical Center 12-98, Davies Medical Center 1-99.

Breast Cancer Prevention, Medical Grand Rounds, St. Joseph’s Medical Center, Burbank, California 1-99.

Targeted Therapy in Colorectal Cancer, Medical Grand Rounds, CPMC; Burbank; Por tland; Seattle; Anchorage; Medford; Racine; 8/03- present.

  • Current Title
  • Principal Positions Held
  • Education
  • Licenses and Certifications
  • Honors and Awards
  • Professional Activities
  • Publications

Caroline Marie Behler, M.D.

Hematologist-Oncologist
Pacific Hematology Oncology Associates
California Pacific Medical Center, San Francisco, CA

Assistant Clinical Professor
Department of Medicine, University of California, San Francisco, CA

Principal Positions Held
Assistant Clinical Professor of Medicine
University of California, San Francisco Department of Medicine
Division of Hematology and Oncology
Malignant Hematology and Bone Marrow Transplant
August 2007-April 2012

Chief, Malignant Hematology
San Francisco V.A. Medical Center
August 2007 – April 2012

Education

University of California
San Francisco Hematology/Oncology Fellowship, 2004-07

University of California, San Francisco
Internal Medicine Residency, 2001-04

University of Washington School of Medicine
Doctor of Medicine with Honors, 2001

University of Washington School of Public Health
Master of Science, Pathobiology, 1999

University of Washington College of Arts and Sciences Honors Program
Bachelor of Science, Cell and Molecular Biology, Cum Laude, With Distinction, 1994

Licences and Certifications
Diplomate, American Board of Internal Medicine: Hematology, 2008
Diplomate, American Board of Internal Medicine: Oncology, 2007
Diplomate, American Board of Internal Medicine: Internal Medicine, 2004

Honors and Awards
Excellence in Teaching Award
Haile T. Debas Academy of Medical Educators
University of California, San Francisco, 2010

Alpha Omega Alpha National Medical Honor Society, 2000

Hematology Award, American Federation for Medical Research, 1998

Phi Beta Kappa, University of Washington, 1993

Professional Affiliation
American Society of Hematology, 2004-present

Peer Reviewed Publications

1. Wieduwilt MK, Valles F, Behler CM, Hwang J, Issa S, McDermott M, Treseler P, O’Brien J, Shuman MA, Cha S, Damon LE and Rubenstein JL. Immunochemotherapy with Intensive Consolidation for Primary CNS Lymphoma: A Pilot Study and Prognostic Assessment by Diffusion-Weighted MRI, manuscript submitted.

2. Lu CM, Zhou L, Wang E, Feng S, Sebastian S, Behler C. Development of refractory anemia with ring sideroblasts associated with thrombocytosis from pre-existing refractory anemia with ring sideroblasts through acquisition of Jak2 V617F mutation. Leuk Lymphoma. 2011; [Epub ahead of print]

3. Van Allen EM, Miyake T, Gunn N, Behler CM, Kohlwes J. Off-label use of rituximab in a multipayer insurance system. J Oncol Pract. 2011;7(2):76-9.

4. Behler CM, Terrault NA, Etzell JE, Damon LE. Rituximab therapy for pure red cell aplasia due to anti-epoetin antibodies in a woman treated with epoetin-alfa: a case report. J Med Case Reports. 2009; 3: 7335.

5. Behler CM, Vittinghoff E, Lin F, Chung RT, Peters MG, Robbins GK, Volberding PA. Hematologic Toxicity Associated with Interferon-Based Hepatitis C Therapy in HIV-1 Co-Infected Subjects. Clinical Infectious Diseases, 2007; 44(10): 1375-1383.

6. Behler CM, Shade SB, Gregory K, Abrams DI, Volberding PA. Anemia and HIV in the Antiretroviral Era: Potential Significance of Testosterone. AIDS Research and Human Retroviruses 2005; 21(3): 200-6.

7. VM, Ketteler M, Frank RD, Schmitt H, Floege J, Behler CM, Riehl J. Bone pain with scintigraphy suggestive of widespread metastases - do not forget phosphate. Brandenburg Nephrology Dialysis Transplantation 2002; 17(3): 504-7.

8. VanDevanter DR, Choongkittaworn NM, Dyer KA, Aten J, Otto P, Behler C, Bryant EM, Rabinovitch PS. Pure chromosome-specific PCR libraries from single sorted chromosomes. Proceedings of the National Academy of Sciences USA 1994; 91(13): 5858-5862.

Review Articles and Chapters

1. Caroline Behler, Lawrence Kaplan. AIDS-Related Lymphomas. Management of Hematologic Malignancies. Susan O’Brien, Hagop Kantarjian and Julie Vose, Ed. Cambridge University Press, New York, NY 2011.

2. Behler CM and Kaplan LD. Advances in the Management of HIV-Related Non-Hodgkin Lymphoma. Current Opinion in Oncology 2006 18(5): 437-443.

3. Caroline Behler, Patricia Cornett. Anemia in HIV Infection. Viral and Immunological Malignancies. Atlas of Clinical Oncology. Volberding PA and Palefsky JM, Ed. Black and Decker Inc., Hamilton, Ontario 2006.

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